serum levels of il-17, il-4, and infî³ in serbian patients with early rheumatoid arthritis
نویسندگان
چکیده
background: rheumatoid arthritis (ra) is a chronic, systemic, inflammatory disease with autoimmune etiology, characterized by synovial inflammation and destruction of joint cartilage and bone. there are controversial data about the profile of interleukin-17 (il-17a), interleukin-4 (il-4), and interferon-gamma (infî³), indicating in some studies the key role of il-17, while in others the th1 cytokines. materials and methods: serum samples of 31 early ra patients were evaluated for erythrocytes sedimentation rate (esr), rheumatoid factor (rf), c-reactive protein (crp), anti-cyclic citrullinated peptide antibodies (anti-ccp), and for the tested cytokines (il-17a, il-4, and infî³). disease activity score (das28) calculation was done for all patients. control serum samples were obtained from 29 healthy volunteers. results: the levels of tested cytokines were significantly higher (il-17a, p < 0.001; infî³, p < 0.001; il-4, p < 0.01) in patients with early ra, compared to the healthy controls. in early ra patients, a strong correlation of serum il-17a was found with das28, esr, and crp. also, significant negative correlation was found between serum infî³ levels and the das28 score, indicating that infî³ may play a key role in maintaining immune homeostasis in patients with ra. conclusion: the mean serum il-17a levels in patients with early ra, corresponded with the disease activity and severity. this might highlight the usefulness of the serum il-17a level in defining the activity and predictive patterns, for aggressive disease therapy, and it might express specific therapeutically targets.
منابع مشابه
Serum levels of IL-17, IL-4, and INFγ in Serbian patients with early rheumatoid arthritis
BACKGROUND Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory disease with autoimmune etiology, characterized by synovial inflammation and destruction of joint cartilage and bone. There are controversial data about the profile of interleukin-17 (IL-17A), interleukin-4 (IL-4), and interferon-gamma (INFγ), indicating in some studies the key role of IL-17, while in others the Th1 cytok...
متن کاملRelation between bone mineral density and IL-17 serum levels in Serbian patients with early Rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial inflammation and destruction of joint cartilage and bone. Different cytokines play important role in the processes that cause articular destruction and extra-articular manifestations in RA. The contribution of cytokines representing the Th1 (INF-γ), Th2 (IL-4) and IL-17A to the pathogenesis of early RA and bon...
متن کاملDetection of IL-4, IL-6 and IL-12 Serum Levels in Generalized Aggressive Periodontitis
Background: Periodontitis is a multifactorial chronic inflammatory disease characterized by destruction of tooth-supporting tissues. Environmental and genetic factors as well as the immune system participate in this process. Recent studies have attempted to elucidate the role of cytokine networks involved in periodontal diseases. Objective: To assess and compare the levels of IL-4, IL-6 and IL-...
متن کاملSerum Levels of TNF-α, TNF-αRI, TNF-αRII and IL-12 in Treated Rheumatoid Arthritis Patients
Background: Rheumatoid arthritis (RA) is a chronic multisystem autoimmune disease common in all races and ethnics. Cytokines and cytokines receptors play an important role in RA pathogenesis and clinical presentation. Objective: To investigate the serum levels of TNF-α, TNF-α RI, TNF-α RII and IL-12 in RA patients and healthy control group. Methods: In this study 43 patients fulfilling the revi...
متن کاملreviews Title : IL 17 A and IL 17 F gene polymorphisms in patients with rheumatoid arthritis
متن کامل
Serum Levels of IL-10 and IL-22 Cytokines in Patients with Psoriasis
Background: As a chronic inflammatory condition, psoriasis results from an interaction between genetic and immunologic factors in a predisposing environment. In spite of compelling evidence for the role of T cells and cytokines in psoriasis, interleukin (IL)- 10 and IL-22 have not been sufficiently investigated. Objective: To assess the serum levels of IL-10 and IL-22 in patients with psori...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
journal of research in medical sciencesجلد ۱۹، شماره ۱، صفحات ۰-۰
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023